Route 149 is one of a few "living fossil" highways in Connecticut; these have had no notable changes since their designation in 1932. Even when the Route 2 freeway opened in the 1960s, Route 149's official terminus remained at Old Route 2.
Because of this, the town of Hebron is still served by Route 149 – 0.01 miles of it.
A 2.31-mile stretch leading north from Route 82 to Creek Row is a state scenic road; to the west are views of the Connecticut River and Salmon River. Further north, Route 149 passes through Moodus, the site of the legendary "Moodus Noises", which reportedly inspired otherworldly sounds in the H. P. Lovecraft story "The Dunwich Horror."